Targeting iRhom2 for better treatment of autoimmune diseases

Company

SciRhom GmbH is a pioneering biotech enterprise with the vision to translate advanced scientific findings into game-changing therapies for autoimmune diseases. Building on a detailed understanding of how a major cell-surface protease controls inflammation, SciRhom has worked closely with Prof. Carl Blobel of the Hospital for Special Surgery in New York City (USA) to develop first-in-class humanized antibodies against iRhom2. iRhom2 controls the enzyme TACE, a key node in several disease-causing signaling pathways. Tested in vitro and in mouse models of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), these antibodies potently and selectively inhibit TACE in immune cells, thereby protecting against RA and IBD. By targeting iRhom2/TACE, the SciRhom antibodies simultaneously block several established signaling pathways that are currently targeted individually by drugs approved for autoimmune disorders, including TNF-alpha and IL-6R signaling. Superior efficacy, as demonstrated in preclinical proof-of-principle studies, and an expected favorable safety profile make anti-iRhom2 antibodies prime candidates to outperform standard of care. Four patent families secure exclusivity for anti-iRhom2 inhibitors and provide broad protection against follow-on drugs. Current leading indications in the company’s development pipeline are RA, IBD, and lupus nephritis.

Anti-iRhom2 antibodies: a novel mode of action to tackle autoimmune diseases

  • Simultaneously blocks key pro-inflammatory pathways of TNF-alpha, IL-6, and HB-EGF
  • Potentially restores protective pathways by reactivating MerTK-mediated efferocytosis
  • Exhibits superior efficacy and an expected favorable safety profile

SciRhom GmbH: the expertise and vision
to change lives

  • Founded in 2016 to commercialize over 10 years of applied research
  • Strong financing through a consortium of knowledgeable life science investors
  • The experienced management team has initiated the path to market and secured first-in-kind IP

Management

Dr. Jens Ruhe
Managing Director, Chief Executive Officer
T +49 (0)89 614 2412-31
Ruhe@SciRhom.com

Jens co-founded SciRhom GmbH, formerly SciMab GmbH, in late 2016. He has a longtime experience in signal transduction biology and therapeutic antibody development. As co-founder of U3 Pharma GmbH, Jens was involved in new drug target identification, before he joined Prof. Dr. Axel Ullrich to establish a laboratory and cancer genome project at the Institute of Medical Biology (IMB), Agency of Science, Technology and Research (A*STAR) in Singapore. After the acquisition of U3 Pharma by Daiichi Sankyo, Jens served as Authorized Officer and Director Research & Development. In global teams, he was in charge of preclinical development of early to clinical stage antibody projects, including U3 Pharma’s Patritumab lead program. Jens was trained in genetics and immunology at the University of Konstanz, and obtained his PhD in Molecular Biology from Prof. Dr. Axel Ullrich at the Max Planck Institute of Biochemistry, Martinsried.

Dr. Matthias Schneider
Chief Scientific Officer
T +49 (0)89 614 2412-32
Schneider@SciRhom.com

Matthias co-founded SciRhom GmbH, formerly SciMab GmbH, in late 2016. He is a biologist with an extensive experience in biomarker identification and antibody development. Being with U3 Pharma/Daiichi Sankyo from 2008 to mid 2016, he advanced to the preclinical head of the Patritumab lead program. Matthias studied biology at the University Würzburg and earned his PhD in molecular biology in the lab of Prof. Dr. Axel Ullrich at the Max-Planck-Institute of Biochemistry, where he gained deep insights in GPCR/EGF-Receptor crosstalk in oncology.

Dr. Andreas Jenne
Managing Director, Chief Business Officer
T +49 (0)89 614 2412-36
Jenne@SciRhom.com

Andreas is a co-founder of SciRhom GmbH and served as Chairman of the Board before joining the company’s management team in 2020. Andreas has more than 20 years of executive management experience in the life sciences industry and co-founded six biotechnology companies. Prior to joining SciRhom GmbH he was the CEO of RSP Systems A/S, a Danish medical device company focusing on non-invasive diagnostics. Further professional stations include CEO positions at Kinaxo GmbH (a proteomics service provider sold to Evotec in 2011) and NEO New Oncology AG (a cancer diagnostics company sold to Siemens Healthcare in 2016). Andreas holds a Ph.D. in Chemistry from the Ludwig-Maximilians-University in Munich.

Dr. Jürgen Reeß, MD, PhD
Chief Medical Officer
T +49 (0)89 614 2412-30
Reess@SciRhom.com

Jürgen joined the management team of SciRhom GmbH in 2021. He brings over 20 years of experience in operative and strategic clinical development, most recently as Corporate Senior Vice President of International Project Management at Boehringer Ingelheim Human Pharma. A trained physician and expert leader in the pharmaceutical industry, Jürgen supervised the development, approval, and launch of numerous blockbuster therapies for autoimmune diseases, interstitial lung diseases, central nervous system disorders, and cancer. That success hinged upon Jürgen’s proficiency in fostering productivity and creativity in multidisciplinary teams to meet milestones in nearly 100 projects across several therapy areas. Jürgen holds a medical and doctorate degree from the University of Ulm (Germany), is a board-certified neurologist, and has a strong publication record.

Board of Directors

Prof. Carl Blobel
Scientific Founder

Carl is Professor of Medicine (Rheumatology Division) and of Physiology, Biophysics and Systems Biology at Weill Cornell Medicine, and Chairman of the Arthritis and Tissue Degeneration Program at the Hospital for Special Surgery in New York City. He received his medical degree from the Justus-Liebig University, Giessen (Germany) and his Ph.D. in Biochemistry and Biophysics from the University of California, San Francisco (USA). Carl’s groundbreaking research on iRhom2 revealed its potential as a therapeutic target for autoimmune diseases. His membership on the Board of Directors provides unrivaled knowledge to lay out and steer the technological roadmap of the company and to strengthen the scientific evolution of the product.

 

 

Dr. Wolfgang Baiker
Venture Partner at Wellington Partners

After more than 30 years at Boehringer Ingelheim, Wolfgang is an internationally respected advisor and partner for multiple life science business projects. He holds several positions on boards and committees across academia and industry and, as such, has also taken up interim leadership positions at startups. Having served on the Board of Managing Directors and as President and CEO of Boehringer Ingelheim USA, Wolfgang is a veteran in global pharmaceutical production, development, and project management. He fulfills a key role on the SciRhom Board of Directors in advising the expansion of the company organization and infrastructure with sights on the international market. Wolfgang holds a Doctorate in Medicine from the University of Ulm (Germany) and an MBA from Pace University (USA).

Hans-Ulrich Rabe
Strategic Finance Consultant

Deeply embedded in advising direct investments into high-potential German biotech companies, Hans-Ulrich is a well-established and networked consultant for strategic asset allocation and finance management. He serves on several advisory boards in the biotech industry, having developed strong business acumen from work in the banking and nationwide food wholesale sectors as well as from extensive experience evaluating business opportunities and investment candidates. He rounds off the SciRhom Board of Directors with a wealth of expertise in logistics, risk assessment, and driving improved financial performance.

SciRhom – from meticulous research
to novel antibody therapies

Founded in 2016 at the Innovation and Startup Center (IZB) in Martinsried, Germany, SciRhom builds on the cutting-edge research of Professors Carl Blobel and Axel Ullrich.

Prof. Blobel’s pioneering work on membrane-anchored metalloproteases (ADAMs) revealed iRhoms 1 and 2 as key upstream regulators of ADAM17 (also referred to as TACE), an enzyme that mediates pro-inflammatory signaling via TNF-alpha, IL6-R, and EGFR. That crucial piece to the complex puzzle of immune responses is the Achilles heel that SciRhom leverages to suppress autoimmune disease mechanisms. His research and vision advance the company’s development efforts at the forefront of this novel therapeutic opportunity. Prof. Blobel continues to play an essential role at SciRhom both as a collaborating partner and member of the Board of Directors.

Prof. Ullrich is a world-renowned innovator and catalyst of groundbreaking medications. His extraordinary research track record includes meticulous insights into human signal transduction that underscore the translation of iRhom2 into a novel strategy to tackle autoimmunity and cancer. He contributed to the development of genetically engineered human insulin and the first targeted antibody-based cancer therapy, Herceptin. A lifetime dedicated to science produced one of the most cited bodies of scientific literature in the past 25 years, the establishment of six biotech companies, and numerous awards.

Today, SciRhom has demonstrated the therapeutic potential of iRhom2 inhibitors, expanding the scientific foundation laid by Professors Blobel and Ullrich into a rapidly advancing drug development pipeline on track to bring a promising new therapy to market.

About iRhom2

TACE (TNF-alpha-converting enzyme), also called ADAM17, is an essential regulator of major pathophysiological processes of inflammatory disease, including the TNF-alpha (tumor necrosis factor alpha) and EGFR (epidermal growth factor receptor) signaling pathways (1). The pharmaceutical industry has pursued TACE as a drug target for over a decade. Inhibiting that single enzyme blocks several pro-inflammatory pathways at the same time. However, small molecule TACE inhibitors failed at the clinical stage because blocking TACE directly caused severe side effects (2). The issue is that globally deactivating TACE also shuts down the protective action of the EGFR, as TACE no longer processes the EGFR-ligand TGF-alpha, which is crucial for protecting the skin and intestinal barriers (3,4). In fact, patients lacking TACE activity suffer from severe skin infections and intestinal lesions (5).

iRhom2 (inactive Rhomboid 2 or RHBDF2) offers a promising alternative strategy. The TACE-dependent release of TNF-alpha and other pro-inflammatory mediators from immune cells is regulated by iRhom2 (6-8). As such, inhibiting iRhom2 targets the pro-inflammatory activities of TACE without impacting its protective functions in epithelia, which can be maintained by the related iRhom1 (6-8). iRhom2 knock-out mice are protected against rheumatoid arthritis (7,10), inflammatory arthritis caused by hemophilia (11), and glomerulonephritis caused by systemic lupus erythematosus (12). The mice are normal, healthy, and do not develop the skin or intestinal defects seen in mice and patients deficient in TACE (6-8).

A growing collection of research studies point to iRhom2 as an attractive emerging target across several medical areas, including immunology, inflammation, oncology, infectious and metabolic disease. Thus, inhibiting iRhom2 is a therapeutic opportunity to not only selectively target the pro-inflammatory functions of TACE without causing severe side effects, but also to explore novel mechanisms of action urgently needed for other indications.

  1. Blobel CP. Nature Rev Mol Cell Bio. 2005;6:32-43.
  2. Calligaris M et al. Molecules. 2021;26:944.
  3. Chalaris A et al., J Exp Med. 2010;207(8):1617-1624.
  4. Franzke CW et al., J Exp Med. 2012;209(6):1105-1119.
  5. Blaydon DC et al., N Engl J Med. 2011;365(16):1502-1508.
  6. McIlwain DR et al., Science. 2012;335(6065):229-232.
  7. Issuree PD et al., J Clin Invest. 2013;123(2):928-932.
  8. Adrain C et al., Science. 2012;335(6065):225-228.
  9. Li X et al., Proc Natl Acad Sci U S A. 2015;112(19):6080-6085.
  10. Buckland J., Nature Rev Rheumatol. 2013;9(3):136.
  11. Haxaire C et al., Blood. 2018;132(10):1064-1074
  12. Qing X et al., J Clin Invest. 2018;128(4):1397-1412.

Contact

Jens Ruhe
CEO
T +49 (0)89 614 2412-31

SciRhom GmbH
Am Klopferspitz 19
82152 Martinsried
Germany

Press Release

November 18, 2021
Munich, Germany

SciRhom announces changes to the management team and the appointment of a Board of Directors

Launching the next phase of company growth, a new Chief Medical Officer will head up clinical development of proprietary anti-iRhom2 antibodies with the support of accomplished scientists, life science executives, and financial experts.

Munich, Germany, November 18, 2021 – SciRhom GmbH, a therapeutic antibody developer, announced today the addition of Dr. Jürgen Reeß to the management team as Chief Medical Officer. At the same time, the company is strengthening its business and scientific strategy with the establishment of a Board of Directors. The three members of the Board, Prof. Carl Blobel, Dr. Wolfgang Baiker, and Mr. Hans-Ulrich Rabe, will be instrumental in steering the company along a successful path through the next phase of its development. In January 2022, Dr. Andreas Jenne, currently Chief Business Officer of SciRhom, will move from management and join the Board of Directors as a fourth member.

SciRhom has taken critical steps in advancing their first-in-class antibodies against iRhom2 towards clinical development. Proof-of-principle studies demonstrated preclinical efficacy of the drug candidates in protecting mice against rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). The antibodies suppress iRhom2, thereby inhibiting tumor necrosis factor-alpha-convertase (TACE; also known as ADAM17), which conversely blocks several disease-causing signaling pathways. Achievement of this milestone also marks the beginning of the next stage in product development and company progress.

“SciRhom is an agile enterprise,” explains Chief Executive Officer Dr. Jens Ruhe. “As we move into this exciting new development phase, we’ve fine-tuned company structures to ensure that our ranks include top expertise to guarantee successful outcomes. We are in an extraordinary position to have such renowned and experienced partners join our efforts. Each member of our management team and our Board of Directors plays an indispensable role in swiftly moving our innovative therapy concept from our labs to patients with debilitating autoimmune diseases.”

Dr. Jürgen Reeß joins the corporate management team to guide the continued evolution of the therapeutic product and coordinate the company’s development pipelines focused on RA, IBD, and systemic lupus erythematosus glomerulonephritis. A trained physician with a medical and doctorate degree from the University of Ulm (Germany), Dr. Reeß has been a longstanding leader in the pharmaceutical industry. He has supervised the development, approval, and launch of numerous blockbuster therapies across several therapy areas, most recently as Corporate Senior Vice President of International Project Management at Boehringer Ingelheim Human Pharma.

The new Board of Directors will include SciRhom co-founder Prof. Carl Blobel, whose groundbreaking research laid the scientific foundation of SciRhom’s technology. Dr. Blobel is Professor of Medicine and of Physiology, Biophysics and Systems Biology at Weill Cornell Medicine, and Chairman of the Arthritis and Tissue Degeneration Program at the Hospital for Special Surgery in New York City (US). His in-depth knowledge of iRhom2 and TACE will guide the technological roadmap of the company and strengthen the scientific evolution of the product.

The second Board member, Dr. Wolfgang Baiker, is an internationally respected advisor and partner for multiple life science business projects. As Venture Partner at Wellington Partners Venture Fund, Dr. Baiker has leveraged his years-long experience as Board member and CEO of Boehringer Ingelheim USA to help rising companies establish themselves in an international market. He is also an investor in SciRhom. Dr. Baiker fulfills a key role in shaping the corporate strategy to grow SciRhom’s organization and infrastructure.

Hans-Ulrich Rabe rounds off the new Board of Directors. A trusted advisor in strategic asset allocation and direct investment in high-potential biotech companies, Mr. Rabe represents a consortium of four private investors – SciRhom’s largest investment group. With strong business acumen and extensive experience in mentoring companies and fostering their development, Mr. Rabe brings a wealth of expertise in logistics, risk assessment, and finance management to fortify the company’s performance.

Having successfully secured seed funding for SciRhom as the Chief Business Officer, Dr. Andreas Jenne will move from corporate management to the Board of Directors in January 2022. A co-founder of SciRhom, Dr. Jenne has comprehensive knowledge of the company. His appointment to the Board of Directors aligns with the seamless transition of SciRhom from startup to product-oriented enterprise.

About iRhom2
TACE (TNF-alpha converting enzyme or ADAM17) controls several major signaling pathways, including TNF-alpha, IL-6, and EGFR signaling. TACE has therefore been considered a potential target to block pro-inflammatory pathways, but direct inhibition of TACE causes severe side effects, such as skin and intestinal lesions. The recent discovery that iRhom2 (inactive Rhomboid 2, RHBDF2) simultaneously regulates the TACE-dependent release of TNF-alpha and of other pro-inflammatory molecules from immune cells provides the exciting opportunity to target the pro-inflammatory activities of TACE while preserving its protective functions. Furthermore, numerous new research studies suggest that iRhom2 is an attractive emerging target for a broad range of therapeutic areas, including immunology, inflammation, oncology, infectious and metabolic diseases.

About SciRhom GmbH
SciRhom GmbH, based in IZB Martinsried, Germany, is a biotech company that translates science into the preclinical and early clinical development of novel biopharmaceuticals for the treatment of life-threatening autoimmune diseases. Based on longstanding academic research and a well-established network of experts, SciRhom was founded in 2016 through a collaboration between academic and industry scientists with profound experience in antibody development. Since then, the company has developed first-in-class anti-iRhom2 antibodies and demonstrated efficacy in preclinical proof-of-principle studies. Four comprehensive patent families cover the anti-iRhom2 antibodies and iRhom2-target epitopes, securing exclusivity and protection against me-too drugs. To date, SciRhom has successfully acquired seed funding from the High-Tech Gruenderfonds (HTGF) and private investors.

For further information, please visit www.SciRhom.com

Contact
SciRhom GmbH
Dr. Andreas Jenne
Phone: + 49 (0)89 614 2412 36
Email: info@SciRhom.com

November 5, 2019
Munich, Germany

SciRhom initiates first-in-class antibody development program to treat major autoimmune diseases

Bench to bedside research provides a new business opportunity: Newly discovered antibodies against iRhom2 block several pro-inflammatory pathways simultaneously, promising significant improvement over current autoimmune therapies.

Munich, Germany, November 5, 2019 – SciRhom GmbH, a therapeutic antibody company, announced today the development of first-in-class antibodies against iRhom2, a key modulator of several major pro-inflammatory signaling pathways, including TNF-alpha signaling. Based on a decade of cutting-edge bench research and the completion of a challenging, yet ultimately successful antibody campaign, SciRhom is now in the unique position to pursue the development of monoclonal antibodies against iRhom2 for the treatment of major autoimmune diseases.

iRhom2 is a protein that controls the tumor necrosis factor-alpha-convertase (TACE; also known as ADAM17), a set of molecular scissors that activates several crucial signaling pathways, including TNF-alpha (tumor necrosis factor-alpha) and other disease-related signaling 1-6. Blocking TACE, however, raises major concerns about side effects, as TACE-deficient patients show severe skin and intestinal defects 7. In contrast, antibodies against iRhom2 would have the unique advantage over TACE-targeted therapies of simultaneously blocking several TACE-dependent disease-associated pro-inflammatory pathways without causing lesions in the skin and intestinal barrier. Moreover, antibodies against iRhom2 are expected to be superior over anti-TNF-alpha biologics due to their ability to interfere with other important pro-inflammatory pathways. This concept has been validated using iRhom2 knockout mice, which are normal and healthy, but are protected from Rheumatoid Arthritis (RA) and glomerulonephritis caused by Systemic Lupus Erythematosus 8,9.

These proof-of-concept studies were primarily conducted by Professor Dr. Carl Blobel, co-founder of SciRhom and pioneer of the TACE/ADAM17 field, and his colleague, Professor Dr. Jane Salmon. Prof. Blobel is Program Director of the Arthritis and Tissue Degeneration Program at Hospital for Special Surgery (HSS) in New York, USA, one of the world’s top-ranking academic medical centers in Rheumatology and musculoskeletal health.

From these promising results, SciRhom has identified iRhom2-specific antibodies that block TNF-alpha release by TACE and is currently advancing the preclinical development of its first-in-class anti-iRhom2 antibodies towards IND-enabling studies. SciRhom was founded and is led by a highly experienced management team with an excellent track record in antibody drug development that consists of Dr. Jens Ruhe, co-founder of U3 Pharma and former Director R&D at U3 Pharma / Daiichi Sankyo and Dr. Matthias Schneider, previously Preclinical Head of the Patritumab lead program at U3 Pharma / Daiichi Sankyo. In addition to Professor Dr. Carl Blobel, the co-founders of SciRhom are Professor Dr. Axel Ullrich, biotech pioneer, former Director at the Max Planck Institute of Biochemistry and recent recipient of the prestigious Lasker Award, Dr. Andreas Jenne, serial biotech entrepreneur, and HSS. To date, SciRhom has secured about EUR 7 million in seed funding from the High-Tech Gruenderfonds (HTGF), HSS and private investors.

“We are delighted about the excellent and close collaboration with Professor Blobel and HSS, the outstanding work of our team and the strong support by all of our shareholders. Our joint efforts led to the successful generation of first-in-class antibodies against the novel and highly promising target iRhom2, which are protected by the filing of two strong patent applications,” said Dr. Jens Ruhe. “Based on the novel mechanism of action, this approach promises to be a significantly more effective and much safer therapy for autoimmune disease patients. Backed by the clinical excellence of HSS in Rheumatology we are now thrilled to take our anti-iRhom2 antibodies into the clinic as expediently as possible.”

“With the launch of SciRhom we are fulfilling a vision our teams have pursued for more than a decade. We are excited by the opportunity to advance our bench to bedside research into clinical development to provide novel targeted treatment options for patients with debilitating and life-threatening autoimmune diseases,” commented Prof. Dr. Carl Blobel. “iRhom2 provides a unique and completely new approach for the inhibition of several disease-causing pathways simultaneously, including TNF-alpha signaling. We have identified antibodies with a unique profile, showing potent inhibition of iRhom2/TACE without affecting TACE-dependent pathways that are essential for normal physiology. We hope that these efforts will ultimately give clinicians superior treatment options to improve the quality of life of patients.”

 

About iRhom2
TACE (TNF-alpha converting enzyme or ADAM17) controls several major signaling pathways, including TNF-alpha signaling 1,2,5,6. TACE has therefore been considered a potential target for blocking pro-inflammatory pathways, but blocking TACE could cause severe side effects, such as skin and intestinal lesions 7. The recent discovery that iRhom2 (inactive Rhomboid 2, RHBDF2) simultaneously regulates the TACE-dependent release of TNF-alpha and of other pro-inflammatory molecules from immune cells provided the exciting opportunity to target the pro-inflammatory activities of TACE, while preserving its protective functions 3,4,8,9. A major hurdle to translating this concept into the clinic has now been cleared through the identification of function-blocking antibodies against iRhom2.

About SciRhom GmbH
SciRhom GmbH, based in IZB Martinsried, Germany, is a biotech start-up company that translates science into the preclinical and early clinical development of novel biopharmaceuticals for the treatment of life-threatening diseases. Improving autoimmune disease therapies is the central aspiration of SciRhom. Based on longstanding academic research and a well-established network of experts, SciRhom was founded in late 2016 through a collaboration between scientists from academia and scientists with profound experience in antibody development. Two patent families cover the anti-iRhom2 antibodies and iRhom2-target epitope. To date, SciRhom has secured about EUR 7 million in seed funding from the High-Tech Gruenderfonds (HTGF), HSS and private investors.
For further information, please visit www.SciRhom.com.

About High-Tech Gruenderfonds (HTGF)
High-Tech Gruenderfonds (HTGF) is a seed investor that finances high-potential, tech-driven startups. With EUR 895.5 million in total investment volume across three funds and an international network of partners, HTGF has already helped forge more than 560 startups since 2005. Driven by their expertise, entrepreneurial spirit and passion, its team of experienced investment managers and startup experts help guide the development of young companies. HTGF’s focus is on high-tech startups in a range of sectors, including software, media, internet, hardware, automation, health care, chemistry and life sciences. Investors in this public-private partnership include the Federal Ministry for Economic Affairs and Energy, the KfW Capital and further 34 industrial companies. For more Information visit high-tech-gruenderfonds.de.

About HSS
HSS is the world’s leading academic medical center focused on musculoskeletal health. At its core is Hospital for Special Surgery, nationally ranked No. 1 in orthopedics (for the tenth consecutive year), No. 3 in rheumatology by U.S. News & World Report (2019-2020), and named a leader in pediatric orthopedics by U.S. News & World Report “Best Children’s Hospitals” list (2019-2020). Founded in 1863, the Hospital has one of the lowest infection rates in the country and was the first in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center four consecutive times. The global standard total knee replacement was developed at HSS in 1969. An affiliate of Weill Cornell Medical College, HSS has a main campus in New York City and facilities in New Jersey, Connecticut and in the Long Island and Westchester County regions of New York State. In addition, HSS will be opening a new facility in Florida in early 2020. In 2018, HSS provided care to 139,000 patients and performed more than 32,000 surgical procedures, and people from all 50 U.S. states and 80 countries travelled to receive care at HSS. There were more than 37,000 pediatric visits to the HSS Lerner Children’s Pavilion for treatment by a team of interdisciplinary experts. In addition to patient care, HSS leads the field in research, innovation and education. The HSS Research Institute comprises 20 laboratories and 300 staff members focused on leading the advancement of musculoskeletal health through prevention of degeneration, tissue repair and tissue regeneration. The HSS Global Innovation Institute was formed in 2016 to realize the potential of new drugs, therapeutics and devices. The HSS Education Institute is the world’s leading provider of education on musculoskeletal health, with its online learning platform offering more than 600 courses to more than 21,000 medical professional members worldwide. Through HSS Global Ventures, the institution is collaborating with medical centers and other organizations to advance the quality and value of musculoskeletal care and to make world-class HSS care more widely accessible nationally and internationally. www.hss.edu.

 

Contact
SciRhom GmbH
Dr. Jens Ruhe
Phone: +49 89 614 241 230
Email: info@SciRhom.com

 

References
1. Black R, Rauch CT, Kozlosky CJ, et al. A metalloprotease disintegrin that releases tumour-necrosis factor-α from cells. Nature. 1997;385:729-733.
2. Moss ML, Jin S-LC, Milla ME, et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature. 1997;385:733-736.
3. McIlwain DR, Lang PA, Maretzky T, et al. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science. 2012;335(6065):229-232.
4. Adrain C, Zettl M, Christova Y, Taylor N, Freeman M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science. 2012;335(6065):225-228.
5. Blobel CP. ADAMs: key players in EGFR-signaling, development and disease. Nat Rev Mol Cell Bio. 2005;6:32-43.
6. Dusterhoft S, Babendreyer A, Giese AA, Flasshove C, Ludwig A. Status update on iRhom and ADAM17: It’s still complicated. Biochim Biophys Acta Mol Cell Res. 2019;1866(10):1567-1583.
7. Blaydon DC, Biancheri P, Di WL, et al. Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med. 2011;365(16):1502-1508.
8. Issuree PD, Maretzky T, McIlwain DR, et al. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest. 2013;123(2):928-932.
9. Qing X, Chinenov Y, Redecha P, et al. iRhom2 promotes lupus nephritis through TNF-alpha and EGFR signaling. J Clin Invest. 2018;128(4):1397-1412.